Identification of genes targeted by microRNAs.
نویسنده
چکیده
miRNAs (microRNAs) are recently discovered regulators of gene expression. They target mRNAs that contain partially complementary sites to the miRNA. The level of complementarity is different between target site-miRNA pairs, and finding target genes has proved to be a bigger challenge than expected. The present paper reviews the different approaches to predict and experimentally identify genes targeted by miRNAs.
منابع مشابه
Identification of microRNAs in corpus luteum of pregnancy in buffalo (Bubalus bubalis) by deep sequencing
This study was aimed to identify miRNAs of corpus luteum (CL) in buffaloes during pregnancy. For this study, CL (n=2) were collected from gravid uteri of buffalo and RNA was isolated. Following this, the purity and integrity of RNA was checked and used for deep sequencing using Illumina Hiseq 2500 platform. The reads’ quality was checked prior to in silico analyses viz. identification of conser...
متن کاملDifferential genes expression analysis of invasive aspergillosis: a bioinformatics study based on mRNA/microRNA
Invasive aspergillosis is a severe opportunistic infection with high mortality in immunocompromised patients. Recently, the roles of microRNAs have been taken into consideration in the immune system and inflammatory responses. Using bioinformatics approaches, we aimed to study the microRNAs related to invasive aspergillosis to understand the molecular pathways involved in the disease pathogenes...
متن کاملبررسی بیوانفورماتیکی میانکنش بین میکرو RNAها با ژن‌های دخیل در عود مجدد سرطان پستان درمان شده با تاموکسیفن
Background and Objective: Tamoxifen is the most commonly used treatment for the patients with breast cancer called ER +, which prevents the expression of genes that are effective in the growth and proliferation of cancer cells by estrogen. Resistant to Tamoxifen is a major clinical problem in breast cancer treatment. In recent studies, the role of microRNAs in tamoxifen resistance has been rais...
متن کاملComparing MicroRNA Target Gene Predictions Related to Alzheimer's Disease Using Online Bioinformatics Tools
Introduction: The prediction of microRNAs related to target genes using bioinformatics tools saves time and costs of the experimental analyses. In the present study, the prediction of microRNA target genes relevant to Alzheimer’s Diseases (AD) were compared with the experimentally reported data using different bioinformatics tools. Method: A total of 41 microRNAs associated with 21 essential ge...
متن کاملComparing MicroRNA Target Gene Predictions Related to Alzheimer's Disease Using Online Bioinformatics Tools
Introduction: The prediction of microRNAs related to target genes using bioinformatics tools saves time and costs of the experimental analyses. In the present study, the prediction of microRNA target genes relevant to Alzheimer’s Diseases (AD) were compared with the experimentally reported data using different bioinformatics tools. Method: A total of 41 microRNAs associated with 21 essential ge...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 36 Pt 6 شماره
صفحات -
تاریخ انتشار 2008